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Cancer STEM cells are what your oncologist should target

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Dr. Weeks’ Comment: The debate continues – as did the debate about whether the earth is flat or not – but the top researchers in oncology agree with two revolutionary concepts:  1)  cancer STEM cells (which are made “more numerous and more virulent” by conventional cancer treatments (chemo and radiation therapy)  are the lethal part of a tumor (not the cancer TUMOR cells!)  which makes them the new and appropriate target for cancer therapy   and   2:  the best agents to successfully address cancer STEM cells are cheap anti-inflammatory agents.  SOUL – an organic non-GMO drink made from 3 anti-inflammatory seeds is a foundation food for smart people fighting cancer. 

 

Cancer stem cells – the current status of an old concept: literature review and clinical approaches

Lukasz FulawkaPiotr Donizy and Agnieszka Halon

Biological Research 2014, 47:66  doi:10.1186/0717-6287-47-66

Published: 10 December 2014

Abstract (provisional)

As regards their morphology and biology, tumours consist of heterogeneous cell populations. The cancer stem cell (CSC) hypothesis assumes that a tumour is hierarchically organized and not all of the cells are equally capable of generating descendants, similarly to normal tissue. The only cells being able to self-renew and produce a heterogeneous tumour cell population are cancer stem cells. CSCs probably derive from normal stem cells, although progenitor cells may be taken into consideration as the source of cancer stem cells. CSCs reside in the niche defined as the microenvironment formed by stromal cells, vasculature and extracellular matrix. The CSC assays include FACS sorting, xenotransplantation to immunodeficient mice (SCID), incubation with Hoechst 33342 dye, cell culture in non-adherent conditions, cell culture with bromodeoxyuridine. CSCs have certain properties that make them resistant to anticancer therapy, which suggests they may be the target for potential therapeutic strategies.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

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